Attack rate of subclinical post-streptococcal glomerulonephritis in siblings

Sabina Sultana1, Farid Ahmed2, Sarwar Ferdaus3, Md. Nurul Hossain4, Biplob Kumar
Basak5, Asma Ferdous6, Mirza Manjurul Haque7

Abstract
Background: It is well known that post-streptococcal glomerulonephritis may occur
sub-clinically, but there are few publications regarding sub-clinical form of the
disease.
Objectives: To estimate the incidence of sub-clinical disease, among the siblings of
index cases (35) having clinical post-streptococcal glomerulonephritis.
Methods: In this prospective study one hundred and five siblings were investigated
1- 7 days after the admission of the index cases. The diagnosis of sub- clinical disease
was based on the presence of abnormal urine analysis, hypocomplementemia and
increased antistreptolysin O titer.
Results: Abnormal urine analysis in the form of both hematuria & proteinuria was
found in 22(20.9%) siblings. The incidence of nephritis among 105 siblings was
13(12.4%). Among the siblings clinical post streptococcal glomumerulonephritis were
found in 4 (3.8%) cases and sub-clinical disease in 9 (8.6%) cases. Five siblings
(4.8%) had abnormal urine analysis which could not be explained by appropriate
test.
Conclusion: Contact Siblings have risk for the development of clinical or sub clinical
post-streptococcal glomerulonephritis. Those contacts with unexplained urinary
abnormalities might have sub-clinical nephritis in evolution.

Key Words: Attack rate, subclinical post-streptococcal glomerulonephritis, siblings.

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