Methotrexate - The Gold Standard Drug in Pediatric Rheumatology

Probir Kumar Sarkar

Introduction
Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune system suppressant. It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and for medical abortions. Low-dose weekly MTX has emerged as one of the most useful agents in the treatment of rheumatic diseases in children, and it has become the first-choice second-line agent in childhood arthritis, and in some cases arguably a first-line agent. It is also used in many other chronic inflammatory disorders.

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