Naphrogenic Diabetes Insipidus

Mafroza Nahid1, Md. Jahangir Alam2, Probir Kumar Sarker3, A T M Azharul Haque4, Hasan Mahmud Abdullah5

Regulation of water intake and excretion helps maintain extracellular fluid tonicity, within a narrow range, which is crucial for proper cell functions. Maintenance of water balance is primarily dependent on an intact thirst mechanism, vasopressin synthesis and renal tubular responsiveness to vasopressin action. Diabetes insipidus (DI) is a heterogeneous clinical syndrome of disturbance in water balance characterized by the passage of large volumes of dilute urine and the presence of an inordinate thirst.

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