Role of Beclomethasone Dipropionate in inhalation form in reducing relapse in patients with frequent relapsing nephrotic syndrome with wheeze

AK Ghosh1, F Ahmed2, I Jahan3, PK Sarker4, M Hanif5

Abstract
Background: There is a strong association between nephrotic syndrome and atopy.
Thirty to 60% of nephrotic children are atopic. After each exposure of allergen to
respiratory system, these patients relapse. By preventing exposure of allergen to
respiratory system relapse can be reduced. The use of Beclomethasone Dipropionate
will reduce wheeze & in this way it will reduce the number of relapses and the dose of
steroid.
Objective: This study was aimed to evaluate the effectiveness of Beclomethasone
Dipropionate in inhalation form in patients with frequent relapsing nephrotic
syndrome with wheeze.
Study design & Methodology: This prospective case control study was conducted
for a period of 18 months at Nephrology Unit of Dhaka Shishu Hospital. Thirty
paediatric patients with idiopathic nephrotic syndrome who were atopic in the form
of wheeze were divided into two groups. Group-I the study group, the patients of this
group were treated with Beclomethasone Dipropionate in inhalation form with usual
oral salbutamol with prednisolone. Another 15 patients of control group were treated
with usual salbutamol with prednisolone.
Results: In this study, increased number of relapse was found after each sort of
respiratory tract infection. The comparative study showed significant reduction of
dose of steroid in study group and it was statistically significant (p<0.05). After
treatment, the mean dose of steroid in study group was 9.5±3.4 mg/m2/day & control
was 19.1±4.8 mg/m2/day. The study showed the mean number of relapse after
treatment in study group was 1.47±0.52 and in control was 3.07± 0.70. The study
had shown significant reduction in number of relapse in study group and it was
statistically significant (p<0.05). The comparative study had shown statistically
significant reduction of dose of steroid, number of relapse, steroid toxicity in study
group.
Conclusion: Beclomethasone Dipropionate in inhalation form is more effective than
usual oral salbutamol in reducing relapse in patients with frequent relapsing nephrotic
syndrome with wheeze.

Key Words: Nephrotic syndrome, Beclomethasone Dipropionate, Atopy, Relapse.

Download PDF