Subacute Sclerosing Pan-Encephalitis (SSPE): A ten year experience in Dhaka Shishu (Children) Hospital

Subacute Sclerosing Pan-Encephalitis (SSPE): A ten year experience in Dhaka Shishu (Children) Hospital
AZM Mosiul Azam1, Mustafa Mahbub2, Suraj Chandra Majumdar3, Selina Husna Banu4, Naila Zaman Khan5


Introduction: Number of Subacute Sclerosing Panencephalitis (SSPE) in hospital
patients remain unchanged since 2003 although measles immunization coverage has
increased to about 88%.
Objective: To see the clinical and laboratory findings of children presenting with
SSPE and to correlate with measles and its immunization.
Methods : SSPE patients in Neuroscience Department of Dhaka Shishu Hospital
were categorized clinically in differrent stages. Diagnosis was based upon history of
deteriorating neurological functions, typical clinical signs of SSPE, EEG findings
and positive measles antibody titers in CSF. Socio-economic status, history of measles
and immunization were recorded.
Results : Since January 2002 till August 2011, 82 cases were diagnosed. All children
had normal development prior to the appearance of neurological signs. Sixty two
(75.6%) cases had been immunized with measles vaccine of whom 56 (68%) gave no
history of measles. Most of the cases came to hospital at stage 3 (42.7%) and 2 (33%).
Fifty two (63.4%) came from rural areas, and the rest were mainly from Dhaka city.
EEG feature was suggestive of SSPE in 70(85%) cases.
Conclusion : Recent cases of SSPE among children admitted in Dhaka Shishu
Hospital has raised concerns about its public health importance. SSPE is still existing
at an alarming state in our country despite good measles immunization coverage.

Keywords: SSPE, children, measles vaccine

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