The Influence of Family History and Atopy of Asthma in Occurrence of Pediatric Asthma: A Single Center Experience

Md Kamruzzaman1, Nazia Hossain2, Hossain Shahid Kamrul Alam3, Akhand Tanzih Sultana4, Jotsna Ara Begum5, Mohammod Jobayer Chisti6

Abstract
Background:
Asthma is a common disorder with increasing prevalence in children.
World Health organization (WHO) estimates that approximately 500,000 annual
hospitalizations in individuals aged 18 y or younger) are due to asthma. However,
data on the influence of family history as well as atopy in developing childhood
asthma in developing including Bangladesh is scarce.
Objective: This study attempts to analyze the clinical records of 100 pediatric asthma
patients with variable family history and personal history of atopic disease.
Methods: It was a retrospective study that was conducted in the department of
Pediatric Respiratory Medicine (Pulmonology), Dhaka Shishu (Children) Hospital,
Dhaka, Bangladesh from May 2016 to May 2017. We retrospectively analyzed the 100
cases between 2 years to 12 years of age visited in our outpatient and asthma clinic
during study period.
Results: Out of 100 children of asthma, 29 (29%) were between 2 to 5 year, 48 (48%)
between 5-8 years, 23 (23%) more than 8 years. The proportion of male was higher
than female. Of the hundred children, 63% were found to have a positive family
history of atopy and 37% did not have any family history, and 51% were found to
have a positive family history of bronchial asthma, and 12% have a family history of
allergic rhinitis, dermatitis or conjunctivitis. Out of the 63 (63%) children with family
history of bronchial asthma, 44 (86%) had the positive parental history (35%) had
maternal history, 51% had paternal history), 14% children had a positive history in
grandparents. Also 17 (17%) children had a positive family history of allergic rhinitis,
57 (57%) children had personal history of atopy.
Conclusion: The results of our study further underscore the clinical importance of
assessing and intervening in the family relational processes during treating children
with asthma.
Keywords: Bronchial Asthma, Atopy.

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